Oxycodone Powder is a highly addictive opioid pain reliever used to treat moderate to severe pain. This semisynthetic opiate can be found in medications by itself or in combination with other pain relievers.
Oxycodone Powder can be administered orally, intranasally, via intravenous, intramuscular, or subcutaneous injection, or rectally. The bioavailability of oral administration of oxycodone averages within a range of 60 to 87%, with rectal administration yielding the same results; intranasal varies between individuals with a mean of 46%.
After a dose of conventional (instant-release) oral oxycodone, the onset of action is 10 to 30 minutes,and peak plasma levels of the drug are attained within roughly 30 to 60 minutes;in contrast, after a dose of OxyContin (an oral controlled-release formulation), peak plasma levels of oxycodone occur in about three hours.The duration of instant-release oxycodone is 3 to 6 hours, although this can be variable depending on the individual.
Side effects of Oxycodone Powder
When the protective coating is removed, the drug is even more hazardous, causing side effects such as:
A sudden drop in blood pressure.
Slow or irregular breathing.
Cardiac arrest and death.
Synthesized from an organic compound found in opium, oxycodone is a potent opioid drug that is used to treat moderately severe to severe pain. For people who suffer from chronic conditions like cancer or degenerative arthritis, oxycodone can allow optimal functioning and improve quality of life. But when the drug is abused, this controlled narcotic can quickly cause chemical dependence and addiction. Like other opiates, oxycodone can cause a fatal overdose when you ingest too much of the drug. Because of the dangers of abuse and overdose, oxycodone and the drugs that contain it are classified as Schedule II controlled substances.
Serious side effects of oxycodone include reduced sensitivity to pain (beyond the pain the drug is taken to reduce), euphoria, anxiolysis, feelings of relaxation, and respiratory depression.Common side effects of oxycodone include constipation (23%), nausea (23%), vomiting (12%), somnolence (23%), dizziness (13%), itching (13%), dry mouth (6%), and sweating (5%).Less common side effects (experienced by less than 5% of patients) include loss of appetite, nervousness, abdominal pain, diarrhea, urine retention, dyspnea, and hiccups.
Oxycodone in combination with naloxone in managed-release tablets, has been formulated to both deter abuse and reduce “opioid-induced constipation”.
Oxycodone is metabolized by the enzymes CYP3A4 and CYP2D6, and its clearance therefore can be altered by inhibitors and inducers of these enzymes.(For lists of CYP3A4 and CYP2D6 inhibitors and inducers, see here and here, respectively.) Natural genetic variation in these enzymes can also influence the clearance of oxycodone, which may be related to the wide inter-individual variability in its half-life and potency.
Ritonavir or lopinavir/ritonavir greatly increase plasma concentrations of oxycodone in healthy human volunteers due to inhibition of CYP3A4 and CYP2D6. Rifampicin greatly reduces plasma concentrations of oxycodone due to strong induction of CYP3A4. There is also a case report of fosphenytoin, a CYP3A4 inducer, dramatically reducing the analgesic effects of oxycodone in a chronic pain patient.Dosage or medication adjustments may be necessary in each case.